Mesothelioma used to be a rare disease, but because of the widespread use of asbestos it has now been described as an epidemic around the world. There has been an explosion in knowledge about mesothelioma in the past few years, partly stimulated by the formation of the International Mesothelioma Interest Group network. This book represents a state-of-the-art review of the disease, from laboratory through to the bedside, from diagnostic procedures through to treatment and from imaging and early detection through to medico-legal aspects. It will be of interest to any clinician or scientist with any involvement in asbestos-related diseases.
'This book should be of interest to those taking care of patients with mesothelioma, and would make a good addition to the library of professionals concerned with occupational lung disease.'
Mesothelioma is a multiauthored book that aims to provide a comprehensive overview of the epidemiology, biology, diagnosis, and treatment of malignant pleural mesothelioma. Edited by Drs. Bruce Robinson and Philippe Chahinian (from Perth, Australia, and New York City, respectively), the book brings together an international group of authors, most of whom are acknowledged experts on this disease. The selection of authors highlights the fact that mesothelioma, though an uncommon disease in many countries, is a considerable problem internationally.
The strongest focus of the book is on the epidemiology of malignant pleural mesothelioma. Of the 20 chapters, 7 discuss the epidemiology and history of the disease in North America, Europe, Australia, South Africa, and Japan. One of these chapters chronicles how its author, Christopher Wagner, now deceased, and his colleagues established the link between exposure to asbestos and mesothelioma in South Africa circa 1960, despite initial skepticism from physicians elsewhere. Chapters devoted to the pathology of mesothelioma and to staging and surgery, gene therapy, photodynamic therapy, molecular pathogenesis (including the role of simian virus 40), and immunotherapy are well written, generally accurate, and thorough.
A chapter on the medicolegal aspects of mesothelioma is a useful and highly relevant part of the book in the light of the large volume of litigation concerning asbestos that is related to mesothelioma. In contrast, chapters on clinical and palliative care and on imaging are not so well organized and lack detail. More attention could have been given to descriptions of the clinical and radiologic presentation according to disease stage, and the discussion of the comparative merits of computed tomographic and magnetic resonance imaging could have been enhanced with additional illustrations.
The discussion of palliative care is cursory and would have benefited from an expert discussion of the methods of pain management. Although the role of pleuroscopy is addressed in a chapter by C. Boutin, a leader in this technique, current clinical practice in North America does not parallel this European experience, and some comment in that regard would have been beneficial. Radiation therapy and chemotherapy are grouped together in a single chapter written by Chahinian, a medical oncologist.
A full chapter on radiation techniques and results written by a radiation oncologist would have been worthwhile. Finally, the organization of the chapters is puzzling. Chapters on epidemiology are placed at both the beginning and the end of the book, and the progression of the chapters in between is not entirely logical. As is true of all textbooks, this book is not absolutely current because of the inherent delay between the writing of the individual chapters and publication. Although a decade ago this delay would not have made a difference for a book dealing with mesothelioma, today it does. Advances in biology and clinical care are now occurring at a rapid pace in this disease, and therefore some of the information presented is subtly out of date.
Overall, however, this book provides an excellent review for the practicing clinician. There are few textbooks addressing mesothelioma, and this one is a welcome addition to the literature. Valerie W. Rusch, M.D
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